Drug interactions
Amiodarone + Cyclosporine
Severity: Moderate
Amiodarone and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can increase cyclosporine concentrations, and cyclosporine may raise amiodarone levels. This risks cyclosporine nephrotoxicity and amiodarone adverse effects.
What this interaction means in plain words
Amiodarone and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amiodarone inhibits CYP3A4 and P-gp, reducing cyclosporine clearance; cyclosporine may inhibit amiodarone metabolism.
What to do
Monitor cyclosporine trough levels and renal function, reducing the cyclosporine dose as needed. Monitor ECG for amiodarone effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Cyclosporine?
MediHelp rates the interaction as moderate. Amiodarone and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone can increase cyclosporine concentrations, and cyclosporine may raise amiodarone levels. This risks cyclosporine nephrotoxicity and amiodarone adverse effects.
How serious is the interaction between Amiodarone and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, reducing the cyclosporine dose as needed. Monitor ECG for amiodarone effects.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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