Drug interactions
Amiodarone + Dabrafenib
Severity: Moderate
Amiodarone and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower amiodarone concentrations, reducing efficacy. Both drugs can also prolong the QT interval, so the combined effect on cardiac repolarization is a concern.
What this interaction means in plain words
Amiodarone and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing amiodarone clearance, with additive QT prolongation.
What to do
Monitor ECG, electrolytes and arrhythmia control. Adjust the amiodarone dose or consider alternatives if the response is lost or QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Amiodarone with Dabrafenib?
MediHelp rates the interaction as moderate. Amiodarone and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower amiodarone concentrations, reducing efficacy. Both drugs can also prolong the QT interval, so the combined effect on cardiac repolarization is a concern.
How serious is the interaction between Amiodarone and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and arrhythmia control. Adjust the amiodarone dose or consider alternatives if the response is lost or QTc rises.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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