Drug interactions
Amiodarone + Dextroamphetamine
Severity: Moderate
Amiodarone and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2D6 and may raise dextroamphetamine exposure. Increased stimulant effects can cause tachycardia, hypertension and arrhythmia, which is important in patients needing an antiarrhythmic.
What this interaction means in plain words
Amiodarone and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Amiodarone inhibition of CYP2D6 metabolism of dextroamphetamine, with opposing cardiovascular effects.
What to do
Monitor heart rate, blood pressure and rhythm, and use the lowest effective stimulant dose. Reduce the dose if cardiovascular stimulation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Amiodarone with Dextroamphetamine?
MediHelp rates the interaction as moderate. Amiodarone and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP2D6 and may raise dextroamphetamine exposure. Increased stimulant effects can cause tachycardia, hypertension and arrhythmia, which is important in patients needing an antiarrhythmic.
How serious is the interaction between Amiodarone and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and rhythm, and use the lowest effective stimulant dose. Reduce the dose if cardiovascular stimulation occurs.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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