Drug interactions
Amiodarone + Dienogest / estradiol valerate
Severity: Minor
Amiodarone and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may modestly raise exposure to estradiol and dienogest through CYP3A4 inhibition. This may increase hormonal adverse effects such as breast tenderness, headache and irregular bleeding.
What this interaction means in plain words
Amiodarone and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Amiodarone inhibits CYP3A4, which contributes to the metabolism of dienogest and estradiol.
What to do
No dose adjustment is usually needed; monitor for hormonal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Amiodarone and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may modestly raise exposure to estradiol and dienogest through CYP3A4 inhibition. This may increase hormonal adverse effects such as breast tenderness, headache and irregular bleeding.
How serious is the interaction between Amiodarone and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for hormonal adverse effects.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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