Drug interactions
Amiodarone + Doxorubicin
Severity: Moderate
Amiodarone and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise doxorubicin concentrations, increasing myelosuppression and potentially cardiotoxicity. Both agents can affect cardiac function and rhythm.
What this interaction means in plain words
Amiodarone and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Doxorubicin belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein by amiodarone may reduce doxorubicin efflux and clearance.
What to do
Monitor blood counts, ECG and left ventricular function throughout treatment. Consider an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Doxorubicin
Frequently asked questions
Can I take Amiodarone with Doxorubicin?
MediHelp rates the interaction as moderate. Amiodarone and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may raise doxorubicin concentrations, increasing myelosuppression and potentially cardiotoxicity. Both agents can affect cardiac function and rhythm.
How serious is the interaction between Amiodarone and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, ECG and left ventricular function throughout treatment. Consider an alternative antiarrhythmic if feasible.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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