Drug interactions
Amiodarone + Epinephrine
Severity: Moderate
Amiodarone and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can provoke arrhythmias and in some settings shorten or alter repolarisation, while amiodarone prolongs the QT interval. In cardiac arrest they are routinely used together, but outside resuscitation the combination may increase arrhythmia risk.
What this interaction means in plain words
Amiodarone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Why it happens
Pharmacodynamic: catecholamine-induced arrhythmogenesis combined with amiodarone repolarisation delay.
What to do
Use both as indicated in resuscitation protocols. In non-emergency settings, use the lowest effective epinephrine dose and monitor ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Epinephrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Amiodarone with Epinephrine?
MediHelp rates the interaction as moderate. Amiodarone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can provoke arrhythmias and in some settings shorten or alter repolarisation, while amiodarone prolongs the QT interval. In cardiac arrest they are routinely used together, but outside resuscitation the combination may increase arrhythmia risk.
How serious is the interaction between Amiodarone and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use both as indicated in resuscitation protocols. In non-emergency settings, use the lowest effective epinephrine dose and monitor ECG.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
