Drug interactions
Amiodarone + Etoposide
Severity: Moderate
Amiodarone and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and may increase etoposide exposure, especially absorption of oral etoposide. This could heighten myelosuppression and gastrointestinal toxicity, though clinical data are limited.
What this interaction means in plain words
Amiodarone and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Etoposide belongs to Oncology.
Why it happens
P-glycoprotein inhibition by amiodarone may increase etoposide absorption and reduce its efflux.
What to do
Monitor complete blood counts closely and watch for increased etoposide toxicity. Reduce the etoposide dose if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporine + Etoposide Major
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
Frequently asked questions
Can I take Amiodarone with Etoposide?
MediHelp rates the interaction as moderate. Amiodarone and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and may increase etoposide exposure, especially absorption of oral etoposide. This could heighten myelosuppression and gastrointestinal toxicity, though clinical data are limited.
How serious is the interaction between Amiodarone and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and watch for increased etoposide toxicity. Reduce the etoposide dose if marked myelosuppression occurs.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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