Drug interactions
Amiodarone + Fentanyl transmucosal
Severity: Moderate
Amiodarone and Fentanyl transmucosal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and can raise fentanyl exposure, increasing sedation and respiratory depression risk. Amiodarone's long half-life means the effect persists after stopping it.
What this interaction means in plain words
Amiodarone and Fentanyl transmucosal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by amiodarone reduces fentanyl clearance.
What to do
Titrate fentanyl cautiously, monitor respiratory rate and sedation, and reduce the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Fentanyl transmucosal?
MediHelp rates the interaction as moderate. Amiodarone and Fentanyl transmucosal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 and can raise fentanyl exposure, increasing sedation and respiratory depression risk. Amiodarone's long half-life means the effect persists after stopping it.
How serious is the interaction between Amiodarone and Fentanyl transmucosal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate fentanyl cautiously, monitor respiratory rate and sedation, and reduce the dose as needed.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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