Drug interactions
Amiodarone + Fentanyl
Severity: Moderate
Amiodarone and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 moderately and may raise fentanyl concentrations, increasing the risk of respiratory depression and sedation. Both drugs can also cause bradycardia.
What this interaction means in plain words
Amiodarone and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated fentanyl metabolism by amiodarone.
What to do
Monitor for sedation, respiratory depression and bradycardia, and reduce the fentanyl dose if needed. Take extra care when starting or stopping amiodarone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Fentanyl?
MediHelp rates the interaction as moderate. Amiodarone and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 moderately and may raise fentanyl concentrations, increasing the risk of respiratory depression and sedation. Both drugs can also cause bradycardia.
How serious is the interaction between Amiodarone and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and bradycardia, and reduce the fentanyl dose if needed. Take extra care when starting or stopping amiodarone.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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