Drug interactions
Amiodarone + Glecaprevir / pibrentasvir
Severity: Moderate
Amiodarone and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glecaprevir and pibrentasvir inhibit P-glycoprotein, and amiodarone is a P-gp substrate and inhibitor, so exposure of either may rise. Increased amiodarone levels may cause bradycardia and QT prolongation. Symptomatic bradycardia has been reported with amiodarone and direct-acting antivirals, mostly with sofosbuvir regimens.
What this interaction means in plain words
Amiodarone and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual P-glycoprotein inhibition altering efflux of both drugs.
What to do
Monitor heart rate and ECG during the first weeks of co-therapy. Reduce amiodarone dose if bradycardia or QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Amiodarone and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both glecaprevir and pibrentasvir inhibit P-glycoprotein, and amiodarone is a P-gp substrate and inhibitor, so exposure of either may rise. Increased amiodarone levels may cause bradycardia and QT prolongation. Symptomatic bradycardia has been reported with amiodarone and direct-acting antivirals, mostly with sofosbuvir regimens.
How serious is the interaction between Amiodarone and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG during the first weeks of co-therapy. Reduce amiodarone dose if bradycardia or QT prolongation develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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