Drug interactions
Amiodarone + Hydrocortisone
Severity: Minor
Amiodarone and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer and amiodarone may modestly raise corticosteroid exposure. Clinically relevant changes in either drug are uncommon and usually small. Both drugs can contribute to electrolyte disturbances, which matters for arrhythmia risk.
What this interaction means in plain words
Amiodarone and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone and P-glycoprotein inhibition by amiodarone, with limited clinical significance.
What to do
No routine dose change is needed; monitor serum potassium and magnesium and the ECG in patients on prolonged systemic hydrocortisone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Hydrocortisone?
MediHelp rates the interaction as minor. Amiodarone and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer and amiodarone may modestly raise corticosteroid exposure. Clinically relevant changes in either drug are uncommon and usually small. Both drugs can contribute to electrolyte disturbances, which matters for arrhythmia risk.
How serious is the interaction between Amiodarone and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor serum potassium and magnesium and the ECG in patients on prolonged systemic hydrocortisone.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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