Drug interactions
Amiodarone + Infigratinib
Severity: Moderate
Amiodarone and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is metabolized by CYP3A4, and amiodarone as a CYP3A4 inhibitor may raise its exposure and toxicity, including hyperphosphatemia and ocular effects.
What this interaction means in plain words
Amiodarone and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by amiodarone reduces infigratinib clearance.
What to do
Monitor for infigratinib adverse effects, including serum phosphate, and consider a dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Infigratinib?
MediHelp rates the interaction as moderate. Amiodarone and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib is metabolized by CYP3A4, and amiodarone as a CYP3A4 inhibitor may raise its exposure and toxicity, including hyperphosphatemia and ocular effects.
How serious is the interaction between Amiodarone and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infigratinib adverse effects, including serum phosphate, and consider a dose reduction.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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