Drug interactions
Amiodarone + Irinotecan liposomal
Severity: Moderate
Amiodarone and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP3A4 and P-glycoprotein, potentially altering the disposition of irinotecan and its active metabolite SN-38. Increased exposure could worsen neutropenia and diarrhea.
What this interaction means in plain words
Amiodarone and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amiodarone inhibits CYP3A4 and P-glycoprotein, affecting irinotecan metabolism and efflux.
What to do
Monitor blood counts and for severe diarrhea, and consider an alternative antiarrhythmic if feasible. Adjust irinotecan per toxicity guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Amiodarone and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may inhibit CYP3A4 and P-glycoprotein, potentially altering the disposition of irinotecan and its active metabolite SN-38. Increased exposure could worsen neutropenia and diarrhea.
How serious is the interaction between Amiodarone and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for severe diarrhea, and consider an alternative antiarrhythmic if feasible. Adjust irinotecan per toxicity guidance.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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