Drug interactions
Amiodarone + Isoniazid
Severity: Moderate
Amiodarone and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may modestly raise amiodarone levels through CYP3A4 inhibition, and both drugs can cause hepatotoxicity. The combination may increase the risk of liver injury and amiodarone toxicity.
What this interaction means in plain words
Amiodarone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Isoniazid belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by isoniazid reducing amiodarone metabolism, together with additive hepatotoxic potential.
What to do
Monitor liver function tests and ECG during co-therapy. Watch for amiodarone toxicity such as bradycardia or QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Isoniazid?
MediHelp rates the interaction as moderate. Amiodarone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may modestly raise amiodarone levels through CYP3A4 inhibition, and both drugs can cause hepatotoxicity. The combination may increase the risk of liver injury and amiodarone toxicity.
How serious is the interaction between Amiodarone and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and ECG during co-therapy. Watch for amiodarone toxicity such as bradycardia or QT prolongation.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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