Drug interactions
Amiodarone + Lily of the valley
Severity: Moderate
Amiodarone and Lily of the valley: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides that slow AV conduction and can cause arrhythmias. Combined with amiodarone, which also slows conduction, bradycardia and heart block are more likely.
What this interaction means in plain words
Amiodarone and Lily of the valley can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on sinus and AV node conduction.
What to do
Avoid herbal products containing lily of the valley in patients taking amiodarone. If used, monitor ECG and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Lily of the valley?
MediHelp rates the interaction as moderate. Amiodarone and Lily of the valley can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lily of the valley contains cardiac glycosides that slow AV conduction and can cause arrhythmias. Combined with amiodarone, which also slows conduction, bradycardia and heart block are more likely.
How serious is the interaction between Amiodarone and Lily of the valley?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid herbal products containing lily of the valley in patients taking amiodarone. If used, monitor ECG and heart rate.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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