Drug interactions
Amiodarone + Marijuana
Severity: Moderate
Amiodarone and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol can inhibit CYP3A4 and may raise amiodarone concentrations. Cannabis can also cause tachycardia and affect cardiac rhythm, complicating arrhythmia management.
What this interaction means in plain words
Amiodarone and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cannabinoids inhibit CYP3A4 and CYP2C enzymes, reducing amiodarone metabolism.
What to do
Ask patients about cannabis use and counsel on cardiac risks. Monitor heart rate and ECG if use continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Marijuana, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Marijuana?
MediHelp rates the interaction as moderate. Amiodarone and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabinoids such as cannabidiol can inhibit CYP3A4 and may raise amiodarone concentrations. Cannabis can also cause tachycardia and affect cardiac rhythm, complicating arrhythmia management.
How serious is the interaction between Amiodarone and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about cannabis use and counsel on cardiac risks. Monitor heart rate and ECG if use continues.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
