Drug interactions
Amiodarone + Mestranol
Severity: Minor
Amiodarone and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and could modestly raise exposure to mestranol, an estrogen used in oral contraceptives. Clinical consequences are not well documented and are expected to be small.
What this interaction means in plain words
Amiodarone and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by amiodarone reducing efflux of mestranol; clinical relevance is unestablished.
What to do
No routine adjustment is needed. Watch for increased estrogenic adverse effects such as breast tenderness, nausea or hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Mestranol?
MediHelp rates the interaction as minor. Amiodarone and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits P-glycoprotein and could modestly raise exposure to mestranol, an estrogen used in oral contraceptives. Clinical consequences are not well documented and are expected to be small.
How serious is the interaction between Amiodarone and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for increased estrogenic adverse effects such as breast tenderness, nausea or hypertension.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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