Drug interactions
Amiodarone + Metformin-sitagliptin
Severity: Minor
Amiodarone and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit renal organic cation transporters and increase metformin exposure. Clinical evidence is limited, but higher metformin levels could raise the risk of gastrointestinal effects or lactic acidosis.
What this interaction means in plain words
Amiodarone and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Possible inhibition of renal tubular cationic transporters (OCT2/MATE), reducing metformin clearance.
What to do
Monitor renal function and glucose control, and watch for signs of metformin toxicity. Reduce the metformin dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Amiodarone and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may inhibit renal organic cation transporters and increase metformin exposure. Clinical evidence is limited, but higher metformin levels could raise the risk of gastrointestinal effects or lactic acidosis.
How serious is the interaction between Amiodarone and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glucose control, and watch for signs of metformin toxicity. Reduce the metformin dose if adverse effects occur.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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