Drug interactions
Amiodarone + Methyclothiazide
Severity: Moderate
Amiodarone and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. This pharmacodynamic risk matters more than any effect on renal tubular handling.
What this interaction means in plain words
Amiodarone and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia potentiate amiodarone's QT-prolonging and proarrhythmic effects.
What to do
Monitor serum potassium and magnesium regularly and replace deficits to keep them in the normal range. Obtain an ECG if electrolyte disturbances develop or other QT-prolonging drugs are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Methyclothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Methyclothiazide?
MediHelp rates the interaction as moderate. Amiodarone and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyclothiazide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. This pharmacodynamic risk matters more than any effect on renal tubular handling.
How serious is the interaction between Amiodarone and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace deficits to keep them in the normal range. Obtain an ECG if electrolyte disturbances develop or other QT-prolonging drugs are added.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
