Drug interactions
Amiodarone + Miconazole vaginal
Severity: Minor
Amiodarone and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP3A4 inhibitor and, although vaginal absorption is low, it can raise levels of CYP3A4 substrates. Amiodarone is a CYP3A4 substrate with a narrow therapeutic margin, so increased exposure could add to QT prolongation and bradycardia. Clinically significant effects are uncommon with short vaginal courses.
What this interaction means in plain words
Amiodarone and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated amiodarone metabolism by systemically absorbed miconazole.
What to do
Short vaginal courses generally need no change. In patients with long-term use or other QT risk factors, monitor heart rate and ECG for QT prolongation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Miconazole vaginal?
MediHelp rates the interaction as minor. Amiodarone and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP3A4 inhibitor and, although vaginal absorption is low, it can raise levels of CYP3A4 substrates. Amiodarone is a CYP3A4 substrate with a narrow therapeutic margin, so increased exposure could add to QT prolongation and bradycardia. Clinically significant effects are uncommon with short vaginal courses.
How serious is the interaction between Amiodarone and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short vaginal courses generally need no change. In patients with long-term use or other QT risk factors, monitor heart rate and ECG for QT prolongation.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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