Drug interactions
Amiodarone + Olodaterol inhaled
Severity: Moderate
Amiodarone and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone prolongs the QT interval, and beta2 agonists such as olodaterol can cause tachycardia, hypokalemia and QT effects. Together they may increase the risk of ventricular arrhythmias, though systemic exposure from inhaled doses is low.
What this interaction means in plain words
Amiodarone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and cardiovascular stimulation, with beta2-agonist-induced hypokalemia.
What to do
Use only at recommended olodaterol doses and monitor ECG, heart rate and serum potassium. Correct hypokalemia and report palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Amiodarone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone prolongs the QT interval, and beta2 agonists such as olodaterol can cause tachycardia, hypokalemia and QT effects. Together they may increase the risk of ventricular arrhythmias, though systemic exposure from inhaled doses is low.
How serious is the interaction between Amiodarone and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only at recommended olodaterol doses and monitor ECG, heart rate and serum potassium. Correct hypokalemia and report palpitations or syncope.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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