Drug interactions
Amiodarone + Paclitaxel protein bound
Severity: Moderate
Amiodarone and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and could increase exposure to paclitaxel, with possible higher rates of myelosuppression and neuropathy. The clinical significance is uncertain and no firm data support a major effect.
What this interaction means in plain words
Amiodarone and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition by amiodarone may reduce paclitaxel efflux and clearance.
What to do
Monitor blood counts and signs of peripheral neuropathy during paclitaxel therapy. Reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Amiodarone and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and could increase exposure to paclitaxel, with possible higher rates of myelosuppression and neuropathy. The clinical significance is uncertain and no firm data support a major effect.
How serious is the interaction between Amiodarone and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of peripheral neuropathy during paclitaxel therapy. Reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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