Drug interactions
Amiodarone + Parecoxib
Severity: Moderate
Amiodarone and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9, which metabolizes valdecoxib, the active metabolite of parecoxib. Valdecoxib exposure may rise, increasing the risk of NSAID adverse effects such as renal, cardiovascular and gastrointestinal events.
What this interaction means in plain words
Amiodarone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9 by amiodarone reduces clearance of valdecoxib.
What to do
Use the lowest effective parecoxib dose for the shortest time. Monitor blood pressure, renal function and signs of gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Parecoxib?
MediHelp rates the interaction as moderate. Amiodarone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP2C9, which metabolizes valdecoxib, the active metabolite of parecoxib. Valdecoxib exposure may rise, increasing the risk of NSAID adverse effects such as renal, cardiovascular and gastrointestinal events.
How serious is the interaction between Amiodarone and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest time. Monitor blood pressure, renal function and signs of gastrointestinal bleeding.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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