Drug interactions
Amiodarone + Ponatinib
Severity: Moderate
Amiodarone and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib may inhibit P-glycoprotein and raise amiodarone levels, adding to amiodarone toxicity. Ponatinib itself carries arrhythmia and cardiovascular risk, so the combination warrants attention.
What this interaction means in plain words
Amiodarone and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Ponatinib belongs to Oncology.
Why it happens
Possible P-glycoprotein inhibition by ponatinib reduces amiodarone efflux; additive cardiac risk.
What to do
Monitor ECG for QT prolongation and bradycardia, and heart rate and blood pressure. Check amiodarone toxicity signs and adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Amiodarone with Ponatinib?
MediHelp rates the interaction as moderate. Amiodarone and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib may inhibit P-glycoprotein and raise amiodarone levels, adding to amiodarone toxicity. Ponatinib itself carries arrhythmia and cardiovascular risk, so the combination warrants attention.
How serious is the interaction between Amiodarone and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QT prolongation and bradycardia, and heart rate and blood pressure. Check amiodarone toxicity signs and adjust the dose if needed.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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