Drug interactions
Amiodarone + Schisandra
Severity: Moderate
Amiodarone and Schisandra: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Schisandra constituents inhibit CYP3A4 and might raise amiodarone concentrations, increasing the risk of bradycardia and QT prolongation. Evidence is limited to pharmacological predictions and small studies.
What this interaction means in plain words
Amiodarone and Schisandra can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by schisandra lignans may reduce amiodarone metabolism.
What to do
Advise patients to avoid schisandra products while taking amiodarone. If used, monitor heart rate and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Schisandra?
MediHelp rates the interaction as moderate. Amiodarone and Schisandra can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Schisandra constituents inhibit CYP3A4 and might raise amiodarone concentrations, increasing the risk of bradycardia and QT prolongation. Evidence is limited to pharmacological predictions and small studies.
How serious is the interaction between Amiodarone and Schisandra?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid schisandra products while taking amiodarone. If used, monitor heart rate and ECG.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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