Drug interactions
Amiodarone + Selumetinib
Severity: Moderate
Amiodarone and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can increase selumetinib exposure, which may worsen its adverse effects such as gastrointestinal toxicity, rash and cardiomyopathy. Amiodarone's long half-life prolongs this effect after it is discontinued.
What this interaction means in plain words
Amiodarone and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Selumetinib belongs to Oncology.
Why it happens
Amiodarone inhibits CYP3A4 (moderate), reducing selumetinib metabolism.
What to do
If the combination cannot be avoided, reduce the selumetinib dose per labeling for CYP3A4 inhibitors and monitor for toxicity. Consider an alternative antiarrhythmic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Amiodarone with Selumetinib?
MediHelp rates the interaction as moderate. Amiodarone and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone can increase selumetinib exposure, which may worsen its adverse effects such as gastrointestinal toxicity, rash and cardiomyopathy. Amiodarone's long half-life prolongs this effect after it is discontinued.
How serious is the interaction between Amiodarone and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination cannot be avoided, reduce the selumetinib dose per labeling for CYP3A4 inhibitors and monitor for toxicity. Consider an alternative antiarrhythmic.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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