Drug interactions
Amiodarone + Sodium iodide i-131
Severity: Moderate
Amiodarone and Sodium iodide i-131: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone contains a large amount of iodine and can saturate the thyroid, reducing radioiodine uptake. This can lower the effectiveness of I-131 for therapy or diagnostic imaging.
What this interaction means in plain words
Amiodarone and Sodium iodide i-131 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition from stable iodine released from amiodarone reduces thyroidal uptake of radioiodine.
What to do
Plan I-131 timing with endocrinology, as the effect of amiodarone can persist for months after stopping. Consider alternative diagnostic or treatment approaches if uptake is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Sodium iodide i-131?
MediHelp rates the interaction as moderate. Amiodarone and Sodium iodide i-131 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone contains a large amount of iodine and can saturate the thyroid, reducing radioiodine uptake. This can lower the effectiveness of I-131 for therapy or diagnostic imaging.
How serious is the interaction between Amiodarone and Sodium iodide i-131?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Plan I-131 timing with endocrinology, as the effect of amiodarone can persist for months after stopping. Consider alternative diagnostic or treatment approaches if uptake is inadequate.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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