Drug interactions
Amiodarone + Sufentanil sl
Severity: Major
Amiodarone and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and may increase sufentanil concentrations and prolong its effects. This can cause excessive sedation and potentially fatal respiratory depression.
What this interaction means in plain words
Amiodarone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated sufentanil metabolism by amiodarone.
What to do
Monitor closely for respiratory depression and sedation, especially when starting or changing amiodarone. Reduce the opioid dose or choose an alternative analgesic if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Sufentanil sl?
MediHelp rates the interaction as major. Amiodarone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits CYP3A4 and may increase sufentanil concentrations and prolong its effects. This can cause excessive sedation and potentially fatal respiratory depression.
How serious is the interaction between Amiodarone and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for respiratory depression and sedation, especially when starting or changing amiodarone. Reduce the opioid dose or choose an alternative analgesic if needed.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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