Drug interactions
Amiodarone + Tezacaftor
Severity: Moderate
Amiodarone and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase exposure to tezacaftor, which is a CYP3A substrate. Higher levels could increase adverse effects of the tezacaftor/ivacaftor combination.
What this interaction means in plain words
Amiodarone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by amiodarone decreases tezacaftor metabolism.
What to do
Use the reduced dosing schedule recommended in the labeling for moderate CYP3A inhibitors with tezacaftor/ivacaftor. Monitor for adverse effects such as transaminase elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Tezacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Tezacaftor?
MediHelp rates the interaction as moderate. Amiodarone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase exposure to tezacaftor, which is a CYP3A substrate. Higher levels could increase adverse effects of the tezacaftor/ivacaftor combination.
How serious is the interaction between Amiodarone and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced dosing schedule recommended in the labeling for moderate CYP3A inhibitors with tezacaftor/ivacaftor. Monitor for adverse effects such as transaminase elevation.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
