Drug interactions
Amiodarone + Thalidomide
Severity: Moderate
Amiodarone and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thalidomide and long-term amiodarone can cause peripheral neuropathy. Concurrent use may raise the risk of sensory or motor nerve damage. Thalidomide can also cause bradycardia, which may add to amiodarone's effects on heart rate.
What this interaction means in plain words
Amiodarone and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Thalidomide belongs to Miscellaneous.
Why it happens
Additive neurotoxicity; additive bradycardic effects.
What to do
Perform periodic neurological assessments and monitor heart rate and ECG. Modify therapy if neuropathy or symptomatic bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thalidomide
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Thalidomide?
MediHelp rates the interaction as moderate. Amiodarone and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thalidomide and long-term amiodarone can cause peripheral neuropathy. Concurrent use may raise the risk of sensory or motor nerve damage. Thalidomide can also cause bradycardia, which may add to amiodarone's effects on heart rate.
How serious is the interaction between Amiodarone and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic neurological assessments and monitor heart rate and ECG. Modify therapy if neuropathy or symptomatic bradycardia develops.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
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