Drug interactions
Amiodarone + Tofacitinib
Severity: Moderate
Amiodarone and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP3A4 and raise tofacitinib exposure modestly. This can increase the risk of infection, cytopenias and other dose-related adverse effects.
What this interaction means in plain words
Amiodarone and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tofacitinib belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated tofacitinib metabolism by amiodarone.
What to do
Monitor for infections and blood count abnormalities. Reduce the tofacitinib dose if the patient also takes a potent CYP2C19 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Tofacitinib?
MediHelp rates the interaction as moderate. Amiodarone and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may inhibit CYP3A4 and raise tofacitinib exposure modestly. This can increase the risk of infection, cytopenias and other dose-related adverse effects.
How serious is the interaction between Amiodarone and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections and blood count abnormalities. Reduce the tofacitinib dose if the patient also takes a potent CYP2C19 inhibitor.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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