Drug interactions
Amitriptyline + Asenapine
Severity: Moderate
Amitriptyline and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval and cause sedation and orthostatic hypotension. Together they may raise the risk of arrhythmia and falls.
What this interaction means in plain words
Amitriptyline and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Asenapine belongs to Central Nervous System.
Why it happens
Additive hERG channel blockade and additive CNS depressant and alpha-adrenergic blocking effects.
What to do
Check baseline ECG and electrolytes and monitor the QTc, especially at higher doses. Avoid other QT-prolonging drugs and monitor for sedation and orthostasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Amitriptyline with Asenapine?
MediHelp rates the interaction as moderate. Amitriptyline and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval and cause sedation and orthostatic hypotension. Together they may raise the risk of arrhythmia and falls.
How serious is the interaction between Amitriptyline and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor the QTc, especially at higher doses. Avoid other QT-prolonging drugs and monitor for sedation and orthostasis.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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