Drug interactions
Amitriptyline + Azelastine-fluticasone
Severity: Moderate
Amitriptyline and Azelastine-fluticasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both azelastine and amitriptyline have sedating antihistaminic properties, so combined use can increase drowsiness and impair alertness. Amitriptyline also adds anticholinergic effects.
What this interaction means in plain words
Amitriptyline and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Azelastine-fluticasone belongs to Respiratory.
Why it happens
Additive CNS depression through histamine H1 blockade.
What to do
Warn patients about drowsiness and avoid driving until tolerance is clear. Consider dose reduction or a nonsedating alternative if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
- Amoxapine + Azelastine-fluticasone Moderate
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Azelastine-fluticasone?
MediHelp rates the interaction as moderate. Amitriptyline and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both azelastine and amitriptyline have sedating antihistaminic properties, so combined use can increase drowsiness and impair alertness. Amitriptyline also adds anticholinergic effects.
How serious is the interaction between Amitriptyline and Azelastine-fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and avoid driving until tolerance is clear. Consider dose reduction or a nonsedating alternative if sedation is troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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