Drug interactions
Amobarbital + Azelastine-fluticasone
Severity: Moderate
Amobarbital and Azelastine-fluticasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a barbiturate that causes marked CNS depression, and azelastine can add drowsiness. Barbiturates also induce CYP3A4 and may reduce fluticasone exposure.
What this interaction means in plain words
Amobarbital and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Azelastine-fluticasone belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antagonism and barbiturate GABA-A potentiation, with CYP3A4 induction.
What to do
Counsel on sedation and avoid alcohol and driving. Use the lowest effective doses and monitor for excessive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amoxapine + Azelastine-fluticasone Moderate
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Azelastine-fluticasone?
MediHelp rates the interaction as moderate. Amobarbital and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is a barbiturate that causes marked CNS depression, and azelastine can add drowsiness. Barbiturates also induce CYP3A4 and may reduce fluticasone exposure.
How serious is the interaction between Amobarbital and Azelastine-fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid alcohol and driving. Use the lowest effective doses and monitor for excessive drowsiness.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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