Drug interactions
Amitriptyline + Canagliflozin-metformin
Severity: Minor
Amitriptyline and Canagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as amitriptyline have occasionally been associated with altered glycemia, including hypoglycemia, in patients on antidiabetic drugs. The effect is inconsistent and usually small with metformin, which rarely causes hypoglycemia alone.
What this interaction means in plain words
Amitriptyline and Canagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Canagliflozin-metformin belongs to Endocrine.
Why it happens
Possible modest effects of tricyclics on insulin sensitivity and glucose handling; the mechanism is not well established.
What to do
No routine adjustment is needed. Monitor blood glucose when starting or stopping amitriptyline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Canagliflozin-metformin?
MediHelp rates the interaction as minor. Amitriptyline and Canagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as amitriptyline have occasionally been associated with altered glycemia, including hypoglycemia, in patients on antidiabetic drugs. The effect is inconsistent and usually small with metformin, which rarely causes hypoglycemia alone.
How serious is the interaction between Amitriptyline and Canagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood glucose when starting or stopping amitriptyline.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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