Drug interactions
Amitriptyline + Chlorpropamide
Severity: Minor
Amitriptyline and Chlorpropamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may influence glucose control, and hypoglycemia has been reported with sulfonylureas. Chlorpropamide has a long half-life, so any hypoglycemia could be prolonged.
What this interaction means in plain words
Amitriptyline and Chlorpropamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Chlorpropamide belongs to Endocrine.
Why it happens
Possible pharmacodynamic enhancement of hypoglycemic effect; mechanism not clearly established.
What to do
Monitor blood glucose when amitriptyline is started or changed and adjust the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Amitriptyline with Chlorpropamide?
MediHelp rates the interaction as minor. Amitriptyline and Chlorpropamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may influence glucose control, and hypoglycemia has been reported with sulfonylureas. Chlorpropamide has a long half-life, so any hypoglycemia could be prolonged.
How serious is the interaction between Amitriptyline and Chlorpropamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when amitriptyline is started or changed and adjust the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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