Drug interactions
Amitriptyline + Diazepam
Severity: Moderate
Amitriptyline and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination increases drowsiness, psychomotor impairment and anticholinergic effects, and raises the fall risk, particularly in older adults. Overdose toxicity is also more dangerous with both drugs.
What this interaction means in plain words
Amitriptyline and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from GABA-A potentiation and the sedative antihistaminic and anticholinergic effects of amitriptyline.
What to do
Use the lowest effective doses and monitor for oversedation, confusion and falls. Avoid in elderly patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Diazepam?
MediHelp rates the interaction as moderate. Amitriptyline and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination increases drowsiness, psychomotor impairment and anticholinergic effects, and raises the fall risk, particularly in older adults. Overdose toxicity is also more dangerous with both drugs.
How serious is the interaction between Amitriptyline and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, confusion and falls. Avoid in elderly patients where possible.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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