Drug interactions
Amitriptyline + Eribulin
Severity: Moderate
Amitriptyline and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and amitriptyline has the same potential at higher exposures. Concurrent use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Amitriptyline and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Eribulin belongs to Oncology.
Why it happens
Additive QT interval prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor ECG periodically during treatment. Keep potassium and magnesium within normal range, and consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Amitriptyline with Eribulin?
MediHelp rates the interaction as moderate. Amitriptyline and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval and amitriptyline has the same potential at higher exposures. Concurrent use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Amitriptyline and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG periodically during treatment. Keep potassium and magnesium within normal range, and consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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