Drug interactions
Amitriptyline + Ezogabine
Severity: Moderate
Amitriptyline and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, particularly at higher doses, and amitriptyline can also lengthen the QT interval. The combination may increase the risk of ventricular arrhythmias. Ezogabine also commonly causes urinary retention, which may be worsened by amitriptyline's anticholinergic effect.
What this interaction means in plain words
Amitriptyline and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with additive effects on urinary retention and CNS depression.
What to do
Monitor ECG when the drugs are combined and correct electrolyte abnormalities. Watch for urinary retention and sedation, and consider an alternative if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Amitriptyline with Ezogabine?
MediHelp rates the interaction as moderate. Amitriptyline and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, particularly at higher doses, and amitriptyline can also lengthen the QT interval. The combination may increase the risk of ventricular arrhythmias. Ezogabine also commonly causes urinary retention, which may be worsened by amitriptyline's anticholinergic effect.
How serious is the interaction between Amitriptyline and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG when the drugs are combined and correct electrolyte abnormalities. Watch for urinary retention and sedation, and consider an alternative if QT risk factors are present.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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