Drug interactions
Amitriptyline + Frovatriptan
Severity: Moderate
Amitriptyline and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonin pathways, so combining a tricyclic antidepressant with a triptan carries a theoretical risk of serotonin syndrome. In practice this combination is often used for migraine prevention and acute treatment and serious reactions are rare.
What this interaction means in plain words
Amitriptyline and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from serotonin reuptake inhibition by amitriptyline and 5-HT1B/1D agonism by frovatriptan.
What to do
Counsel the patient on symptoms of serotonin syndrome such as agitation, tremor, sweating and fever. Review the regimen promptly if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Amitriptyline with Frovatriptan?
MediHelp rates the interaction as moderate. Amitriptyline and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on serotonin pathways, so combining a tricyclic antidepressant with a triptan carries a theoretical risk of serotonin syndrome. In practice this combination is often used for migraine prevention and acute treatment and serious reactions are rare.
How serious is the interaction between Amitriptyline and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin syndrome such as agitation, tremor, sweating and fever. Review the regimen promptly if these occur.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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