Drug interactions
Amitriptyline + Gliclazide
Severity: Minor
Amitriptyline and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline may alter glycemic control and has been reported to enhance hypoglycemia with sulfonylureas in some cases, while also potentially masking symptoms. The effect is generally small and inconsistent.
What this interaction means in plain words
Amitriptyline and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Gliclazide belongs to Endocrine.
Why it happens
Possible additive glucose lowering; mechanism not firmly established.
What to do
Monitor blood glucose when amitriptyline is started or stopped and adjust gliclazide if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Gliclazide?
MediHelp rates the interaction as minor. Amitriptyline and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline may alter glycemic control and has been reported to enhance hypoglycemia with sulfonylureas in some cases, while also potentially masking symptoms. The effect is generally small and inconsistent.
How serious is the interaction between Amitriptyline and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when amitriptyline is started or stopped and adjust gliclazide if needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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