Drug interactions
Amitriptyline + Glyburide-metformin
Severity: Minor
Amitriptyline and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have been associated with changes in glycemic control, and may occasionally enhance glucose lowering or mask hypoglycemic symptoms. Clinical significance is generally small.
What this interaction means in plain words
Amitriptyline and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Mechanism is not firmly established; possible effects on insulin sensitivity and autonomic symptom awareness.
What to do
Monitor blood glucose when starting or stopping amitriptyline and adjust antidiabetic therapy only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Glyburide-metformin?
MediHelp rates the interaction as minor. Amitriptyline and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have been associated with changes in glycemic control, and may occasionally enhance glucose lowering or mask hypoglycemic symptoms. Clinical significance is generally small.
How serious is the interaction between Amitriptyline and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping amitriptyline and adjust antidiabetic therapy only if control changes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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