Drug interactions
Amitriptyline + Glycopyrrolate
Severity: Moderate
Amitriptyline and Glycopyrrolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. In susceptible patients, such as older adults, confusion, ileus or heat intolerance may occur.
What this interaction means in plain words
Amitriptyline and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
Why it happens
Additive antimuscarinic effects from muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma, urinary retention or constipation. Reduce doses or select non-anticholinergic alternatives if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
- Clozapine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Amitriptyline with Glycopyrrolate?
MediHelp rates the interaction as moderate. Amitriptyline and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. In susceptible patients, such as older adults, confusion, ileus or heat intolerance may occur.
How serious is the interaction between Amitriptyline and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma, urinary retention or constipation. Reduce doses or select non-anticholinergic alternatives if effects are troublesome.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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