Drug interactions
Bethanechol + Glycopyrrolate
Severity: Moderate
Bethanechol and Glycopyrrolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrrolate is a muscarinic antagonist and opposes the effects of bethanechol on the bladder and gut. The result is reduced efficacy of one or both drugs.
What this interaction means in plain words
Bethanechol and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Glycopyrrolate belongs to Respiratory.
Why it happens
Competitive muscarinic receptor antagonism opposes bethanechol agonism.
What to do
Avoid concurrent use when bethanechol is intended to stimulate motility or bladder emptying. If necessary, monitor clinical response and adjust doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
- Clozapine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Bethanechol with Glycopyrrolate?
MediHelp rates the interaction as moderate. Bethanechol and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrrolate is a muscarinic antagonist and opposes the effects of bethanechol on the bladder and gut. The result is reduced efficacy of one or both drugs.
How serious is the interaction between Bethanechol and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when bethanechol is intended to stimulate motility or bladder emptying. If necessary, monitor clinical response and adjust doses.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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