Drug interactions
Amitriptyline + Griseofulvin
Severity: Minor
Amitriptyline and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce amitriptyline concentrations through enzyme induction. The antidepressant effect could be diminished, but the clinical impact is probably small.
What this interaction means in plain words
Amitriptyline and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Griseofulvin belongs to Anti Fungals.
Why it happens
Weak induction of CYP enzymes by griseofulvin increases amitriptyline metabolism.
What to do
Monitor for reduced antidepressant response and adjust the amitriptyline dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Griseofulvin?
MediHelp rates the interaction as minor. Amitriptyline and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin may reduce amitriptyline concentrations through enzyme induction. The antidepressant effect could be diminished, but the clinical impact is probably small.
How serious is the interaction between Amitriptyline and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and adjust the amitriptyline dose if needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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