Drug interactions
Amitriptyline + Istradefylline
Severity: Minor
Amitriptyline and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits P-glycoprotein and CYP3A4 and may modestly increase exposure to some substrates. Amitriptyline is affected mainly through other pathways, so the effect is probably small, but tricyclic adverse effects could increase.
What this interaction means in plain words
Amitriptyline and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Weak P-glycoprotein and CYP3A4 inhibition by istradefylline, mainly at 40 mg/day.
What to do
No routine adjustment is needed; watch for sedation, anticholinergic effects or palpitations, especially at the 40 mg dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Amitriptyline with Istradefylline?
MediHelp rates the interaction as minor. Amitriptyline and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses inhibits P-glycoprotein and CYP3A4 and may modestly increase exposure to some substrates. Amitriptyline is affected mainly through other pathways, so the effect is probably small, but tricyclic adverse effects could increase.
How serious is the interaction between Amitriptyline and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for sedation, anticholinergic effects or palpitations, especially at the 40 mg dose.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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