Drug interactions
Amitriptyline + Metformin-pioglitazone
Severity: Minor
Amitriptyline and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline can alter glucose regulation and has occasionally been associated with hypoglycemia or, more often, weight gain and hyperglycemia. The effect on metformin and pioglitazone is inconsistent and usually minor.
What this interaction means in plain words
Amitriptyline and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Unclear; possible effects on insulin sensitivity and appetite, with no established mechanism.
What to do
Monitor blood glucose and weight when amitriptyline is started or stopped, and adjust antidiabetic therapy only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Amitriptyline and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline can alter glucose regulation and has occasionally been associated with hypoglycemia or, more often, weight gain and hyperglycemia. The effect on metformin and pioglitazone is inconsistent and usually minor.
How serious is the interaction between Amitriptyline and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and weight when amitriptyline is started or stopped, and adjust antidiabetic therapy only if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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