Drug interactions
Amitriptyline + Metformin-repaglinide
Severity: Minor
Amitriptyline and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have been associated with alterations in glycemic control, and amitriptyline may occasionally enhance hypoglycemia with antidiabetic agents. The effect is inconsistent and usually of limited clinical importance.
What this interaction means in plain words
Amitriptyline and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Possible pharmacodynamic effect on glucose homeostasis; the mechanism is not well established.
What to do
No dose change is needed routinely. Monitor blood glucose when amitriptyline is started or stopped in patients with diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Metformin-repaglinide?
MediHelp rates the interaction as minor. Amitriptyline and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have been associated with alterations in glycemic control, and amitriptyline may occasionally enhance hypoglycemia with antidiabetic agents. The effect is inconsistent and usually of limited clinical importance.
How serious is the interaction between Amitriptyline and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Monitor blood glucose when amitriptyline is started or stopped in patients with diabetes.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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