Drug interactions
Amitriptyline + Nateglinide
Severity: Minor
Amitriptyline and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline may alter glycemic control and could add to the glucose-lowering effect of nateglinide, a secretagogue that can cause hypoglycemia. The effect is expected to be small.
What this interaction means in plain words
Amitriptyline and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose; mechanism not well established.
What to do
Monitor blood glucose after starting or stopping amitriptyline and educate the patient about hypoglycemia symptoms. Adjust nateglinide only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Amitriptyline with Nateglinide?
MediHelp rates the interaction as minor. Amitriptyline and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline may alter glycemic control and could add to the glucose-lowering effect of nateglinide, a secretagogue that can cause hypoglycemia. The effect is expected to be small.
How serious is the interaction between Amitriptyline and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping amitriptyline and educate the patient about hypoglycemia symptoms. Adjust nateglinide only if needed.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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