Drug interactions
Amitriptyline + Nifedipine
Severity: Minor
Amitriptyline and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may weakly affect P-glycoprotein and could slightly change amitriptyline exposure. No consistent clinically important effect has been established, although both drugs can lower blood pressure.
What this interaction means in plain words
Amitriptyline and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Possible minor P-glycoprotein effect; additive orthostatic hypotension is a separate pharmacodynamic contribution.
What to do
No routine adjustment is needed. Monitor for orthostatic hypotension and tricyclic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Nifedipine?
MediHelp rates the interaction as minor. Amitriptyline and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine may weakly affect P-glycoprotein and could slightly change amitriptyline exposure. No consistent clinically important effect has been established, although both drugs can lower blood pressure.
How serious is the interaction between Amitriptyline and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for orthostatic hypotension and tricyclic response.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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